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liver cells leads to autoimmune ” hepatitis. In mice, acute hepatitis can be induced by concanavalin A treatment, which causes rapid MedChemExpress SNDX 275 activation of CD1d-positive natural killer T cells. These activated NKT cells produce “2991807 large amounts of cytokines, which induce strong inflammation that damages liver tissues. Here we show that PKC-h2/2 mice were resistant to ConA-induced hepatitis due to essential function of PKC-h in NKT cell development and activation. A dosage of ConA that was lethal to wildtype mice failed to induc
