Ee K, Sgagias M, Cowan KH Ectopic expression of von Hippel-Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor development of 786-O cells in nude mouse. Biochem Biophys Res Commun 320: 945950. 9 Cadherin-11 in Kidney Bone Epigenetics metastasis 22. Guise TA Molecular mechanisms of osteolytic bone metastases. Cancer 88: 28922898. 23. Mundy GR Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2: 584593. 24. Pan T, Zhu J, Hwu WJ, Jankovic J The function of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS One 7: e45183. 25. Lee YC, Bilen MA, Yu G, Lin SC, Huang CF, et al. Inhibition of Cell Adhesion by an Anti-cadherin 11 Antibody Prevents Bone Metastasis. Mol Cancer Res. 26. Fukuhara S, Sako K, Noda K, Zhang J, Minami M, et al. Angiopoietin1/Tie2 receptor signaling in vascular quiescence and angiogenesis. Histol Histopathol 25: 387396. 27. Gibney GT, Aziz SA, Camp RL, Conrad P, Schwartz BE, et al. c-Met can be a prognostic marker and possible therapeutic target in clear cell renal cell carcinoma. Ann Oncol 24: 343349. 28. Harshman LC, Choueiri TK Targeting the Hepatocyte Growth Factor/ c-Met Signaling Pathway in Renal Cell Carcinoma. Cancer J 19: 316323. 29. Guise TA, Yin JJ, Thomas RJ, Dallas M, Cui Y, et al. Parathyroid hormone-related protein – isoform is effectively secreted in vitro and enhances breast cancer metastasis to bone in vivo. Bone 30: 670676. 30. Kakonen SM, Mundy GR Mechanisms of osteolytic bone metastases in breast carcinoma. Cancer 97: 834839. 31. Sottnik JL, Keller ET Understanding and targeting osteoclastic activity in prostate cancer bone metastases. Curr Mol Med 13: 626639. 32. Chang SK, Noss EH, Chen M, Gu Z, Townsend K, et al. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A 108: 84028407. 33. Kalluri R, Weinberg RA The fundamentals of epithelial-mesenchymal transition. J Clin Invest 119: 14201428. 34. Thiery JP, Acloque H, Huang RY, Nieto MA Epithelial-mesenchymal transitions in development and illness. Cell 139: 871890. 35. Zeisberg M, Neilson EG Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 14291437. 36. Hazan RB, Qiao R, Keren R, Badano I, Suyama K Cadherin switch in tumor progression. Ann N Y Acad Sci 1014: 155163. 37. Wheelock MJ, Autophagy Shintani Y, Maeda M, Fukumoto Y, Johnson KR Cadherin switching. J Cell Sci 121: 727735. 38. Haviv YS, van Houdt WJ, Lu B, Curiel DT, Zhu ZB Transcriptional targeting in renal cancer cell lines by way of the human CXCR4 promoter. Mol Cancer Ther 3: 687691. 39. Murakami T, Maki W, Cardones AR, Fang H, Tun Kyi A, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic prospective of murine B16 melanoma cells. Cancer Res 62: 73287334. 40. D’Alterio C, Consales C, Polimeno M, Franco R, Cindolo L, et al. Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer. Curr Cancer Drug Targets ten: 772781. 41. Wehler TC, Graf C, Biesterfeld S, Brenner W, Schadt J, et al. Powerful expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease. J Oncol 2008: 626340. 42. Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, et al. Stromal derived factor-1 and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 5: 56. 43. Strewler GJ, Williams RD, Nissenson RA Human renal carcinoma cells generate hypercalcemia in 1315463 the nude mouse and also a novel protein recognized by parathyroid hormone receptors. J Clin.Ee K, Sgagias M, Cowan KH Ectopic expression of von Hippel-Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor development of 786-O cells in nude mouse. Biochem Biophys Res Commun 320: 945950. 9 Cadherin-11 in Kidney Bone Metastasis 22. Guise TA Molecular mechanisms of osteolytic bone metastases. Cancer 88: 28922898. 23. Mundy GR Metastasis to bone: causes, consequences and therapeutic possibilities. Nat Rev Cancer two: 584593. 24. Pan T, Zhu J, Hwu WJ, Jankovic J The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS 1 7: e45183. 25. Lee YC, Bilen MA, Yu G, Lin SC, Huang CF, et al. Inhibition of Cell Adhesion by an Anti-cadherin 11 Antibody Prevents Bone Metastasis. Mol Cancer Res. 26. Fukuhara S, Sako K, Noda K, Zhang J, Minami M, et al. Angiopoietin1/Tie2 receptor signaling in vascular quiescence and angiogenesis. Histol Histopathol 25: 387396. 27. Gibney GT, Aziz SA, Camp RL, Conrad P, Schwartz BE, et al. c-Met is actually a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma. Ann Oncol 24: 343349. 28. Harshman LC, Choueiri TK Targeting the Hepatocyte Development Factor/ c-Met Signaling Pathway in Renal Cell Carcinoma. Cancer J 19: 316323. 29. Guise TA, Yin JJ, Thomas RJ, Dallas M, Cui Y, et al. Parathyroid hormone-related protein – isoform is effectively secreted in vitro and enhances breast cancer metastasis to bone in vivo. Bone 30: 670676. 30. Kakonen SM, Mundy GR Mechanisms of osteolytic bone metastases in breast carcinoma. Cancer 97: 834839. 31. Sottnik JL, Keller ET Understanding and targeting osteoclastic activity in prostate cancer bone metastases. Curr Mol Med 13: 626639. 32. Chang SK, Noss EH, Chen M, Gu Z, Townsend K, et al. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A 108: 84028407. 33. Kalluri R, Weinberg RA The fundamentals of epithelial-mesenchymal transition. J Clin Invest 119: 14201428. 34. Thiery JP, Acloque H, Huang RY, Nieto MA Epithelial-mesenchymal transitions in improvement and disease. Cell 139: 871890. 35. Zeisberg M, Neilson EG Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 14291437. 36. Hazan RB, Qiao R, Keren R, Badano I, Suyama K Cadherin switch in tumor progression. Ann N Y Acad Sci 1014: 155163. 37. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR Cadherin switching. J Cell Sci 121: 727735. 38. Haviv YS, van Houdt WJ, Lu B, Curiel DT, Zhu ZB Transcriptional targeting in renal cancer cell lines via the human CXCR4 promoter. Mol Cancer Ther three: 687691. 39. Murakami T, Maki W, Cardones AR, Fang H, Tun Kyi A, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 62: 73287334. 40. D’Alterio C, Consales C, Polimeno M, Franco R, Cindolo L, et al. Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer. Curr Cancer Drug Targets 10: 772781. 41. Wehler TC, Graf C, Biesterfeld S, Brenner W, Schadt J, et al. Powerful expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease. J Oncol 2008: 626340. 42. Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, et al. Stromal derived factor-1 and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 5: 56. 43. Strewler GJ, Williams RD, Nissenson RA Human renal carcinoma cells make hypercalcemia in 1315463 the nude mouse in addition to a novel protein recognized by parathyroid hormone receptors. J Clin.
