Selho Nacional de Desenvolvimento Cient ico e Tecnol ico/CNPq/Brazil
Selho Nacional de Desenvolvimento Cient ico e Tecnol ico/CNPq/Brazil) and the Research Supporting Foundation of State of Sergipe (Funda o de Amparo ?Pesquisa do Estado de Sergipe/FAPITEC/SE). The authors are grateful to Dr. Sandro Navickiene and Mary Claudine Paix de Matos (Department of Chemistry, Federal University of Sergipe, Brazil) for support and helpful discussions. Author details 1 Department of Physiology, Federal University of Sergipe-UFS, S Crist -SE CEP 49000-100, Brazil. 2Laboratory of Morphology and Structural Biology Science and Technology Institute -ITP, Aracaju, SE CEP 49000-000, Brazil. 3Tiradentes University, Aracaju, SE CEP 49000-000, Brazil. 4Department of Chemistry, Federal University of Sergipe, S Crist , SE 49100-000, Brazil. Received: 8 August 2012 Accepted: 17 July 2013 Published: 28 July 2013 References 1. Die MD, Burger HG, Bone KM, Cohen MM, Teede HJ: Hypericum perforatum with vitex agnus-castus in menopausal symptoms: a randomized, controlled trial. Menopause 2009, 16(Suppl 1):1?. 2. Mello NK: Commentary on black cohosh for the treatment of menopausal PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25112874 symptoms. Menopause 2008, 15(Suppl 5):819?29. 3. BRASIL: Brazilian Ministry of PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27797473 Health. National Agency of Sanitary Surveillance (ANVISA). Resolution – RDC n?4/2010. Registration of Phytotherapic medicines. Bras ia, DF: Di io Oficial da Rep lica Federativa do Brasil, Poder executivo; 2010. 05 de abril de 2010. [Portuguese]. 4. Awodele O, Oreagba IA, Odoma S, Silva JAT, Osunkalu VO: Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae). J Ethnopharmacol 2012, 139:330?36. 5. Elvin-Lewis M: Should we be concerned about herbal remedies? J Ethnopharmacol 2001, 75:141?64. 6. Guimar s AG, Oliveira GF, Melo MS, Cavalcanti SCH, Antoniolli AR, Bonjardim LR, Silva FA, Santos JA, Rocha RF, Moreira JF, Ara o AAS, Gelain DP, Quintans-J ior LJ: Bioassay-guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol. Basic Clin Pharmacol Toxicol 2010, 107:949?57. 7. Komesaroff P, Black CV, Cable V, Sudhir K: Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001, 4(Suppl 2):144?50. 8. Dweck AC: Isoflavones, phytohormones and phytosterols. J Appl Cosmetol 2006, 24:17?3. 9. Sautour M, Miyamoto T, Lacaille-Doubois M: Steroidal saponins and flavan-3-ol glycosides form Dioscorea villosa. Biochem System Ecol 2006, 74:60?3.10. Zand RSR, Jenkins DJA, Diamandis EP: Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta 2001, 312:213?19. 11. Wojcikowski K, Wholmuth H, Johnson DW, Gobe G: Dioscorea purchase STI-571 villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Food Chem Toxicol 2008, 46:3122?131. 12. Hooker E: Final report of the amended safety assessment of Dioscorea villosa (wild yam) root extract. Int J Toxicol 2004, 23:49?4. 13. Faure ED, Chantre P, Mares P: Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2002, 9(Suppl 5):329?34. 14. Albrecht MA, McCarthy BC: Seed germination and dormancy in the medical woodland herbs Collinsonia canadensis L. (Lamiaceae) and Dioscorea villosa L. (Dioscoreaceae). Flora 2006, 201:24?1. 15. Almeida RN, Navarro DS, Barbosa-Filho JM: Plants with central analgesic activity. Phytomedicine 2001, 8:310?22. 16. Gon lves JCR, Oliveira FS, Benedito RB, De Sousa DP, Almeida RN, Ara o DAM: Antin.
