Imately equal quantity. Lixivaptan chemical information Because of this, in therapy, the empirical coverage of all fevers in the ICU with antibiotics just isn’t needed [3]. Leucocytosis occurred immediately after transfusion of NFPC but not soon after transfusion of PFPC. We suggest that IL-8 could contribute to this phenomenon.PTransfer in ICU of febrile neutropenic individuals: identification of danger aspects and potential validation of a prognostic scoreJ Larch?, F Alla, P Maurer*, A G ard* *Service de R nimation M icale, CHU Nancy Brabois 54500 Vandoeuvre les Nancy, France; Service d’Epid iologie et d’Evaluation Cliniques, CHU Nancy H ital Marin, 54000 Nancy, France Objective: Optimal strategy of referral for neutropenic patients from hematology ward to intensive care unit is just not yet well defined. Various severity-of-illness scores employed in ICU happen to be recently tested in hematology wards and have failed to predict accurately sufferers at `high risk’, who could require a pre-emptive transfer in ICU. We performed a case ontrol study in post-chemotherapy neutropenic sufferers (for leukaemia or lymphoma), aimed at identifying early danger elements for ICU transfer. Design: Monocentric, retrospective, case ontrol (equilibration on age, sex, and variety of hemopathy) study comparing febrile neutropenic patients admitted or not in ICU. Outcomes and measurements: Eighty-two individuals happen to be included (41 instances, 41 PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20724077 controls). Sufferers incorporated had been 51 males, have been aged 43 ?17 years. The majority had been hospitalized for an acute myeloblastic leukaemia (56 ), the other folks for acute lymphoblastic leukaemia (30 ) or lymphoma (13 ). The majority of the sufferers had clinical manifestations of infection (62 ) but only 31 a microbiologically demonstration of infection. 61.7 from the sufferers were not in remission at time of admission in ICU. Mortality in ICU was 65.8 . We compared data amongst neutropenic individuals (referred or not referred in ICU) for the duration of their remain in hematology ward. We distinguished an early period (inside 72 hours immediately after the onset of febrile neutropenia) and also a later period (72 hours ahead of transfer in ICU or prior to discharge from hospital). Comparing information amongst these sufferers through the early period highlighted that urea, creatinin, protein C-reactive, and fibrinogen levels considerably elevated whereas hematocrit, platelets and lymphocytes levels have been drastically decreased, in individuals referred in ICU. Employing these `early’ independent threat factors, we define a prognostic score identifying sufferers who could advantage of an early transfer in ICU. A multicenter, prospective study is now becoming performed on a second cohort to validate accuracy, adequacy and reliability of this score. Conclusion: Today, no prognostic score focused on identification of `high-risk’ neutropenic individuals has been yet validated. This study allowed the identification of early danger components independently related with transfer in ICU. The clinical use in haematology wards of such a prognostic score ought to enable earlier pre-emptive transfers in ICU, resulting in far better management and possibly a far better outcome for these patients.PSeptic shock etiology in kidney transplant recipientsFVC De Marco, A Higa, RG Silva, JOM Pestana, OFP Santos Intensive Care Unit, Kidney and Hypertension Hospital `Oswaldo Ramos Foundation’, Rua Borges Lagoa 960, Vila Clementino, CEP 04038-002, S Paulo, Brazil Introduction: Septic shock carries a higher mortality in kidney transplant recipients. As a result, early institution of empiric antimicrobial t.
