37 vs. 120.five, P0.05).Figures 3-6show that administration of G. glabra recovered
37 vs. 120.five, P0.05).Figures 3-6show that administration of G. glabra recovered D-galactose-induced enhance in TNF-, IL-6, IL-1 and NF-kB (33.five vs. 595, P0.05;1.2.14 vs. two.five.33, P0.05; 30.78.1 vs. 49.66.four, P0.05; 57.52.7 vs. 971.two, P0.05), respectively. As shown in Figures 7 and eight, G. glabra improved testosterone and DHEA-S levels (0.49.05 vs. 0.25.03, P0.05; 1.3.34 vs. 0.six.08, P0.05) in aged mice. Effects of R. officinalis in aged mice R. officinalis treatment recovered D-galactose-induced rats by decreasing TBARS (13.two.63 vs. 20.66.88, P0.05), and escalating TAP (167.7.3 vs. 120.five, P0.05) (Figures 1, two). Figures 3-6 show that administration of R. officinalis recovered D-galactoseinduced raise in TNF-, IL-6, IL-1, and NF-kB (422 vs. 595, P0.05; 1.2.two vs. two.five.33, P0.05; 33.five.1 vs. 49.66.4, P0.05; 58.1.8vs. 971.2, P0.05), respectively. As shown in Figures 7 and eight, R. officinalis increased testosterone, (0.46.09 vs. 0.25.03, P0.05) and DHEA-S (1.17.19 vs. 0.6.08, P0.05) in aged mice.Iran J Basic Med Sci, Vol. 16, No. 11, NovMohammadirad A et alAnti-Aging Effects of Some Iranian Folk Medicinal HerbsTBARS (nM)25 20 15 ten 5a b b b b b b b b b bFigure 1. Effects of herbs on serum thiobarbituric acid reactive substances (TBARS) as lipid peroxidation (LPO) marker in aged mice. Information are mean EM of ten animals. ATM Inhibitor list aSignificantly distinctive involving sham group along with other groups at P0.05. bSignificantly different between D-galactose group as well as other groups at P0.05 250 200 TAP (mM) 150 100 50b abbb bbbbbbFigure 2. Effects of herbs on serum total antioxidant power (TAP) of aged mice. Data are imply EM of ten IRAK1 Inhibitor manufacturer animals aSignificantly distinctive involving sham group as well as other groups at P0.05 bSignificantly distinct among D-galactose group and other groups at P0.05IL-1 (pg/ml)50 40 30 20 10a b b b b b b b b b bFigure three. Effects of herbs on serum interleukin-1 beta (IL-1) in aged mice. Data are imply EM of ten animals aSignificantly different in between Sham group along with other groups at P0.05 bSignificantly unique among D-Galactose group and other groups at P0.05 90 75 60 45 30 15TNF- (pg/ml)a b b b b b b b b b bFigure 4. Effects of herbs on serum tumor necrosis factor-alpha (TNF-) in aged mice. Data are mean EM of ten animals aSignificantly various involving Sham group and also other groups at P0.05 bSignificantly distinctive among D-Galactose group and other groups at P0.05.Iran J Simple Med Sci, Vol. 16, No. 11, NovAnti-Aging Effects of Some Iranian Folk Medicinal HerbsMohammadirad A et al3.5 3 2.five 2 1.5 1 0.5a b b b b b b b b b bFigure five. Effects of herbs on serum interleukin 6 (Il-6) in aged mice. Data are mean EM of ten animals a Considerably various between Sham group as well as other groups at P0.05 bSignificantly diverse between D-Galactose group and other groups at P0.05 120 one hundred NF-KB (pg/ml) 80 60 40 20IL-6 (pg/ml)a b b b b b b b b b bFigure six. Effects of herbs on serum NF-kappaB (NF-kB) in aged mice. Data are imply EM of ten animals aSignificantly distinctive between Sham group and also other groups at P0.05 bSignificantly different involving D-Galactose group and also other groups at P0.05 Testosterone (ng/ml) 0.9 0.75 0.6 0.45 0.3 0.15b abbb b b b b bbFigure 7. Effects of herbs on serum testosterone in aged mice. Data are mean EM of ten animals aSignificantly distinct in between Sham group and also other groups at P0.05 bSignificantly various amongst D-Galactose group and also other groups at P0.DHEA-S (ng/ml)1.five 1.two 0.9 0.six 0.3b b abbbbbbbbFigure 8. Effects of herb on serum dehyd.
