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Plague caused by Y. pestis (a Gram unfavorable bacterium) can be a zoonotic infectious disease that has profoundly affected the course of history [1,2] and troubles human populations, leading to millions of deaths. Based on the World Wellness Organization (WHO), plague has been classified as a re-emerging infectious disease [3]. Rodents will be the reservoirs for Y. pestis along with the fleas transmit the mTOR Modulator Purity & Documentation bacteria from rodent to rodent. Infected fleas also transmit bubonic plague, probably the most common type of the disease from rodents to humans [4?]. Humans are infected accidently following bites from fleas getting Y. pestis, by direct make contact with with blood and tissues of infected animals, or by direct aerosol transmission. The aerosol transmission develops lethal pneumonic plague. The intentional aerosolization of Y. pestis in human popu.