Product Name :
DPBQ
Description:
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells.
CAS:
7029-89-2
Molecular Weight:
362.38
Formula:
C24H14N2O2
Chemical Name:
2, 3-diphenyl-5H, 10H-benzo[g]quinoxaline-5, 10-dione
Smiles :
O=C1C2=NC(=C(N=C2C(=O)C2=CC=CC=C12)C1C=CC=CC=1)C1C=CC=CC=1
InChiKey:
BDDRJIAFKGWLMD-UHFFFAOYSA-N
InChi :
InChI=1S/C24H14N2O2/c27-23-17-13-7-8-14-18(17)24(28)22-21(23)25-19(15-9-3-1-4-10-15)20(26-22)16-11-5-2-6-12-16/h1-14H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Estradiol supplier
Additional information:
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA.RLY-2608 supplier DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells.|Product information|CAS Number: 7029-89-2|Molecular Weight: 362.38|Formula: C24H14N2O2|Chemical Name: 2, 3-diphenyl-5H, 10H-benzo[g]quinoxaline-5, 10-dione|Smiles: O=C1C2=NC(=C(N=C2C(=O)C2=CC=CC=C12)C1C=CC=CC=1)C1C=CC=CC=1|InChiKey: BDDRJIAFKGWLMD-UHFFFAOYSA-N|InChi: InChI=1S/C24H14N2O2/c27-23-17-13-7-8-14-18(17)24(28)22-21(23)25-19(15-9-3-1-4-10-15)20(26-22)16-11-5-2-6-12-16/h1-14H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32400180 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ.|References:|Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016;15(1):48-59.Products are for research use only. Not for human use.|
