Product Name :
KRM-III
Description:
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity.
CAS:
79220-94-3
Molecular Weight:
252.33
Formula:
C15H12N2S
Chemical Name:
1,4-diphenyl-2,3-dihydro-1H-imidazole-2-thione
Smiles :
S=C1NC(=CN1C1C=CC=CC=1)C1C=CC=CC=1
InChiKey:
QKOAQVKXZJFMET-UHFFFAOYSA-N
InChi :
InChI=1S/C15H12N2S/c18-15-16-14(12-7-3-1-4-8-12)11-17(15)13-9-5-2-6-10-13/h1-11H,(H,16,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.EPI-743 medchemexpress
Additional information:
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity.|Product information|CAS Number: 79220-94-3|Molecular Weight: 252.33|Formula: C15H12N2S|Chemical Name: 1,4-diphenyl-2,3-dihydro-1H-imidazole-2-thione|Smiles: S=C1NC(=CN1C1C=CC=CC=1)C1C=CC=CC=1|InChiKey: QKOAQVKXZJFMET-UHFFFAOYSA-N|InChi: InChI=1S/C15H12N2S/c18-15-16-14(12-7-3-1-4-8-12)11-17(15)13-9-5-2-6-10-13/h1-11H,(H,16,18)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (396.Fas Ligand Protein, Human (HEK293, N-His) manufacturer 31 mM; Need ultrasonic).PMID:31992688 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.Products are for research use only. Not for human use.|
