Product Name :
ABT-724 trihydrochloride
Description:
ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.
CAS:
587870-77-7
Molecular Weight:
402.75
Formula:
C17H22Cl3N5
Chemical Name:
2-[4-(pyridin-2-yl)piperazin-1-yl]methyl-1H-1,3-benzodiazole trihydrochloride
Smiles :
Cl.Cl.Cl.C(C1NC2=CC=CC=C2N=1)N1CCN(CC1)C1C=CC=CN=1
InChiKey:
AZFUVPBLKQGSRI-UHFFFAOYSA-N
InChi :
InChI=1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Naloxone Autophagy
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors.OGN/Osteoglycin Protein, Mouse (HEK293, His) medchemexpress ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.|Product information|CAS Number: 587870-77-7|Molecular Weight: 402.75|Formula: C17H22Cl3N5|Chemical Name: 2-[4-(pyridin-2-yl)piperazin-1-yl]methyl-1H-1,3-benzodiazole trihydrochloride|Smiles: Cl.Cl.Cl.C(C1NC2=CC=CC=C2N=1)N1CCN(CC1)C1C=CC=CN=1|InChiKey: AZFUVPBLKQGSRI-UHFFFAOYSA-N|InChi: InChI=1S/C17H19N5.PMID:33172342 3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20 mg/mL (49.66 mM; Need ultrasonic). H2O : ≥ 100 mg/mL (248.29 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.|In Vivo:|ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats.|Products are for research use only. Not for human use.|
