A purpurea was not effective to reduce the apoptotic mechanisms induced by gamma-rays in mouse liver. In fact, curcumin was able to slightly enhance DNA fragmentation in all groups. Nevertheless, more studies are needed in order to confirm these findings.3.4. 5.6.7.8. 9.10.11.12.13.14.Conclusions These observations show that curcumin exerts its protective effect by decreasing PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27797473 the LP and improving antioxidant status. These results may provide the molecular basis for the application of curcumin in clinical radiation therapy.Competing interests The authors declare that they have no competing interests. Authors’ contributions ST, AA, and YS designed the study, undertook all experimental work, drafted the initial manuscript and reviewed the manuscript for important intellectual content and read and approved the final version. Author details 1 Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box; 29, Nasr City, Cairo, Egypt. 2Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box; 29, Nasr City, Cairo, Egypt. 3Molecular Biology Department, National Research Centre, P. O. Box: 33211, Dokki, Cairo, Egypt. Received: 1 March 2013 Accepted: 12 September 2013 Published: 21 September 2013 References 1. Fuchs-Tarlovsky V: Role of antioxidants in cancer therapy. Nutrition 2013, 29(1):15?1. 2. Qiao Q, Jiang Y, Li G: Curcumin improves the antitumor effect of X-ray irradiation by blocking the NF-B pathway: an in-vitro study of lymphoma. Anticancer Drugs 2012, 23:597?05.15. 16.17. 18. 19.20.21. 22.23.24.25.26. 27.Nambiar D, Rajamani P, Singh RP: Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy. Mutat Res 2011, 728:139?57. Chen G, Chen Y, Yang N, Zhu X, Sun L, Li G: Interaction between curcumin and mimetic biomembrane. Science China Life Sci 2012, 55:527?32. Plengsuriyakarn T, Viyanant V, Eursitthichai V, Picha P, Kupradinun P, Itharat A, Na-Bangchang K: Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models. BMC Complement Altern Med 2012, 12:23?6. Jagetia GC, Rajanikant GK: Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated radiation. Int Wound J 2012, 9:76?2. Mosieniak G, Sliwinska M, Piwocka K, Sikora E: Curcumin abolishes apoptosis resistance of calcitrol-differentiated HL-60 cells. FEBS Lett 2006, 580:4653?660. Tiwari H, Rao MV: Curcumin supplementation protects from genotoxic effects of arsenic and fluoride. Food Chem Toxicol 2010, 48:1234?238. Leong PK, Chiu PY, Ko KM: Prooxidant-induced VP 63843 site glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin. Biol Pharm Bull 2012, 35(4):464?72. Bar-Sela G, Epelbaum R, Schaffer M: Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr Med Chem 2010, 17:190?97. Thresiamma KC, George J, Kuttan R: Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. J Exp Clin Cancer Res 1998, 17:431?34. Okunieff P, Xu J, Hu D, Liu W, Zhang L, Morrow G, Pentland A, Ryan JL, Ding I: Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int J Rad Oncol, Biol, Physics.
