Ion in mice with acute experimental colitis Post-inflammatory chemical and mechanical hyperalgesia in rodents Behavioural pain response to intraperitoneal injection of acetic acid in rodents Pancreatitis induced by caerulein Islet inflammation in non-obese diabetic mice (genetic model of sort I diabetes) Discomfort behaviour linked with L-arginine-induced necrotizing pancreatitis in rodents Responsiveness of afferent neurones to bladder distension and intravesical acid in rodents Improve in distension-induced afferent signalling and hyper-reflexia connected with experimental inflammation on the rodent urinary bladder Sufferers with neurogenic bladder overactivity and sensory urgency Sufferers with urinary bladder pain and hyperreflexia Form of evidence Hypersensitivity towards the algesic effect of capsaicin Advantageous impact of TRPV1 ablation Attenuation by TRPV1 knockout and 372196-77-5 In Vitro antagonism References Hammer et al. (2008) Bortolotti et al. (2002) Jones et al. (2005, 2007); Miranda et al. (2007)ColonAttenuation by TRPV1 knockout and antagonism Attenuation by TRPV1 antagonismEijkelkamp et al. (2007); Jones et al. (2007); Winston et al. (2007) Ikeda et al. (2001); Rigoni et al. (2003); Tang et al. (2007) Nathan et al. (2001) Razavi et al. (2006); Suri and Szallasi (2008) Wick et al. (2006)Peritoneal cavityPancreas PancreasAttenuation by TRPV1 antagonism Prevention by TRPV1 ablationPancreasAttenuation by TRPV1 antagonismUrinary bladderAttenuation by TRPV1 knockout and antagonism Attenuation by TRPV1 ablation and knockoutBirder et al. (2002); Daly et al. (2007) Jaggar et al. (2001); Charrua et al. (2007)Urinary bladderUrinary bladder Urinary bladderUpregulation of TRPV1 inside the urinary bladder Advantageous impact of TRPV1 ablationBrady et al. (2004); Liu et al. (2007) Bley (2004); Brady et al. (2004); Avelino and Cruz (2006); Cruz and Dinis (2007)TRPV1 ablation refers to pretreatment with capsaicin or resiniferatoxin to defunctionalize afferent neurones.An implication of TRPV1 in heat sensing has extended been envisaged from the effects of capsaicin and resiniferatoxin to cause hypothermia (Szolcsanyi, 1982; Szallasi and Blumberg, 1999). Moreover, pretreatment of rodents with a higher dose of capsaicin to defunctionalize sensory and hypothalamic neurones results in prolonged hyperthermia and impairs the animals’ ability to recognize high ambient temperatures and to mount suitable heat dissipation responses (JancsoGabor et al., 1970a; Szolcsanyi, 1982). As the thermoregulatory behaviour of rats treated with capsaicin as neonates or adults is differentially altered, it has been suggested that peripheral capsaicin-sensitive mechanisms are extra relevant to body temperature regulation than central capsaicinsensitive mechanisms (Dib, 1983; Hajos et al., 1983). It desires to be taken into account, on the other hand, that capsaicininduced ablation of sensory neurones reduces the DRG expression of several thermo-TRP channels like TRPV1, TRPM8 and TRPA1 (Yamashita et al., 2008). TRPV1 is expressed by somatic and visceral sensory neurones that monitor the external environmental and internal body temperature, respectively, and by neurones inside the preoptic/ anterior hypothalamus which functions both as a sensor of local temperature and an integrator of sensory input from the periphery (Figure 2). It’s now emerging that a crucial function of TRPV1 should be to monitor and control core body temperature (Montell and Caterina, 2007). This British Journal of Pharmacology (2008) 155 11.
