Apy (ESRA), The Association of Anaesthetists of Great Britain and Ireland, The Canadian Anesthesiologists’ Society (CAS), The European Society of Anaesthesiology (ESA), The American Academy of Pain Medicine (AAPM), and the American Academy of Hospice and Palliative Medicine (AAHPM). The last day of literature search was July 15, 2020, just before submission in the write-up.ResultsWe were unable to discover any published articles devoted to the subject of perioperative discomfort management in surgical patients infected with COVID19 [see Table 1 for an overview of your articles]. Four articles that were relevant to this topic have been identified. The initial article was written by an international professional panel for the ASRA and ESRA statements on chronic pain practice through the pandemic, which focused on the management of chronic pain through the pandemic with sections on opioids, NSAIDs, and steroid use for COVID19 patients.[11] The second article discussed considerations in multidisciplinary chronic discomfort management in the course of the pandemic.[12] The third report covered considerations and suggestions for neuraxial and peripheral nerve blocks in COVID19 sufferers.[13] The fourth report discussed the sensible considerations for regional anesthesia in an infected or suspected COVID19 patient concerning measures of controlling crosscontamination for anesthesia personnel.[14] Perioperative discomfort management techniques and medicines Early epidemiologic studies classified the clinical circumstances of COVID19 into 3 categories: mild (with mild pneumonia or none), extreme (with dyspnea, hypoxia, or 50 lung tissue TRPV Activator custom synthesis involvement in radiological imaging), and essential(with respiratory failure, shock, or multiorgan dysfunction),[15] as shown in Table 2. In our opinion, this categorization is essential when weighing the risks and added benefits of employing a specific medication for the management of perioperative pain. The major aim for the duration of this pandemic is definitely the safety of individuals and healthcare workers, so surgical procedures TLR7 Agonist list really should be postponed with all the agreement ofMethodsWe searched the PubMed database for the terms “pain,” “pain medicine,” “pain management,” “pain control,” “postoperative discomfort,” “perioperative pain,” “opioids,” “and “analgesia” in combination with “COVID19” and “SARS CoV2”. We also searched for chosen medicationsSaudi Journal of Anesthesia / Volume 15 / Problem 1 / JanuaryMarchAlyamani, et al.: Perioperative discomfort management in COVID19 patientsTable 1: An overview in the articlePerioperative discomfort management techniques and medicationsGeneral Considerations Neuraxial anesthesia and peripheral nerve blocks Opioids Patient-controlled analgesia (PCA Frequently applied analgesic medicines Paracetamol Nonsteroidal anti-inflammatory drugs (NSAIDS) Alpha-1 Agonists Gabapentinoids Ketamine LidocaineNeuraxial anesthesia and peripheral nerve blocks COVID19 will not be a contraindication for neuraxial anesthesia or other regional anesthesia procedures based on ASRA. Qualified societies of regional anesthesia suggest prioritizing regional anesthesia techniques in suspected or confirmed COVID19 patients because airway instrumentation is regarded an aerosolgenerating process.[13,19,20] Furthermore, regional blocks are opioidsparing and may decrease the possibilities for airway obstruction and respiratory depression within the postoperative period.[11,13,21] During a regional block, conversion to a general anesthetic strategy usually remains a possibility. Consequently, it really is recommende.