with logistic regression. ROC-analysis was utilised for the determination of optimal cutoff. P-value 0,05 was thought of as important. Results: Amongst all patients sVTE was diagnosed in 21 (eight , 95 CI: 4,731,3). Median time to diagnosis was 22 (IQR 176,5) days. The optimal cutoff for duration of remedy inside the intensive care unit during the first 30 days was 2 days. The optimal cutoff for the TABLE two Univariate and CysLT2 Antagonist medchemexpress multivariate evaluation of risk elements for sVTE in young children and adolescents with lymphomasUnivariate analysis Characteristic ABO group “Non-O” Volume of mediastinal lymphadenopathy 250 ml ICU hospitalization 2 days Age 12 years Odds ratio (95 CI) three.2 (0.9251.28) six.three (two.496.1) three.six (1.four.eight) eight.8 (two.50.eight) P-value 0.066 0.0001 0.01 0.001 Multivariate analysis Odds ratio (95 CI) four.86 (1.268.65) four.38 (1.592.1) two.92 (0.98.68) 6.7 (1.84.9) P-value 0.02 0.004 0.053 0.volume of mediastinal lymphadenopathy was 250 ml. The optimal cutoff for age was 12 years. Benefits in the univariate and multivariate analysis are presented in the table two.Conclusions: Blood group “Non-O”, volume of mediastinal lymphadenopathy 250 ml and age 12 years are independent risk factors for sVTE in young children and adolescents with lymphomas. These factors might be made use of for additional research of principal antithrombotic prophylaxis in this cohort of individuals.improved morbidity and mortality. Accessible danger prediction tools for identifying patients at higher threat of VTE show poor clinical performance. MicroRNAs (miRNAs) are compact RNAs, which regulate several different cellular processes, are somewhat stable and are Caspase 2 Inhibitor supplier detectable in body fluids. We hypothesize that miRNAs might be utilized to improve VTE prediction in CRC individuals. Aims: The aim of this study is always to recognize novel tumor-expressedPB1103|Identification of Tumor-expressed MicroRNAs Associated with Venous Thrombosis in Colorectal Cancer R.J.S. Anijs; E.H. Laghmani; B. l S.M. Kielbasa; H. Mei; S.C. Cannegieter; F.A. Klok; P.J.K. Kuppen; H.H. Versteeg; J.T. Buijs Leids Universitair Medisch Centrum, Leiden, Netherlands Background: Colorectal cancer (CRC) patients have an elevated danger of building venous thromboembolism (VTE), resulting inmiRNAs associated with VTE. Procedures: In a cohort of 418 CRC individuals diagnosed in between 20012015 at the Leiden University Health-related Center (LUMC), 23 sufferers created VTE 1 year prior to or following cancer diagnosis. Based on availability of frozen tumor material, age, gender and tumor stage, 17 patients with VTE and 18 patients without the need of VTE have been chosen. Tumor cells had been isolated using laser capture microdissection and samples have been subsequently analyzed on the Illumina sequencing platform NovaSeq600 utilizing a 150 bp paired-end sequencing. TheABSTRACT815 of|paired-end raw reads were processed using the BioWDL small-RNA pipeline version 1.two.0 developed at LUMC. Differential miRNA expression was analysed working with edgeR; the Benjamini-Hochberg approach was utilized to adjust p-values for false discovery. Results:Conclusions: We identified 19 tumor-expressed miRNAs substantially expressed in cancer-associated VTE, which might have the possible to serve as novel, non-invasive predictive biomarkers for VTE in CRC.PB1104|The Function of Thrombophilia in Asparaginase Related Venous Thromboembolism in Pediatric and Young Adult Patients Affected by Acute Lymphoblastic Leukemia A. Serrao1; G.M. Assanto1; C. Santoro1; S. Bianchi1; S. Olivieri2; M. Canichella1; A.M. Testi1; A. ChistoliniSapienza University of Rome, Rome, Italy; 2
