Metabolized from AA AA AA AA AA Linoleic acid Linoleic acid EPA EPA EPA Linoleic acid Linoleic acid Linoleic acid AA AA AA -Linolenic acid Enzyme Linoleic Acid JNK1 medchemexpress Metabolism -Linolenic Acid Metabolism AA Metabolism DM 0.0004 0.001 0.313 0.002 0.001 0.701 0.519 0.617 0.027 0.009 0.004 0.002 0.491 0.607 0.597 0.882 0.032 0.0004 p-Value SM 0.005 0.053 0.422 0.052 0.014 0.265 0.025 0.154 0.018 0.057 0.020 0.219 0.069 0.225 0.768 0.518 0.207 0.15(S)-HETE 11(S)-HETE 12(S)-HETE eight(S)-HETE five(S)-HETE 13(S)-HPODE 9(S)-HPODE 15(S)-HEPE 12(S)-HEPE 5(S)-HEPE 13-HODE AA 13(S)-HOTrE TXB2 12(S)-HHTrE 11-dehydro TXB2 EPA -Linolenic acidC20 H32 O3 C20 H32 O3 C20 H32 O3 C20 H32 O3 C20 H32 O3 C18 H32 O4 C18 H32 O4 C20 H30 O3 C20 H30 O3 C20 H30 O3 C18 H32 O3 C20 H32 O2 C18 H30 O3 C20 H34 O6 C17 H28 O3 C20 H32 O6 C20 H30 O2 C18 H30 O15-LOX,GPX4 11-LOX,GPX4 12-LOX,GPX4 8-LOX,GPX4 5-LOX,GPX4 15-LOX 9-LOX 15-LOX,GPX4 12-LOX,GPX4 5-LOX,GPX4 15-LOX Delta6-desaturase 13-LOX COX COX COX Delta6-desaturaseHETE: hydroxyeicosatetraenoic acid; HEPE: hydroxyDNMT1 Species eicosapentaenoic acid; HPODE: hydroperoxylinoleic acid; HODE: hydroxyoctadecadienoic acid; HOTrE: hydroxyoctadecatrienoic acid; TXB2: thromboxane B2; HHTrE: hydroxyheptadecatrienoic acid; EPA: eicosapentaenoic acid; GPx: glutathione peroxidase; LOX: lipoxygenase; COX: cyclooxygenase. , p 0.05; , p 0.01; , p 0.001.Additionally, Figure 3 showed that 19 types of metabolites in a further pathway changed through SCIT, such as polyunsaturated fatty acids metabolites (5 metabolites: 5,9,12octadecatrienoic acid, 4,7,ten,13,16,19-docosahexaenoic acid, four,7,ten,13-docosatetraenoic acid, 7,10,13-eicosatrienoic acid and C16:2n-7,13), monounsaturated fatty acids metabo-Metabolites 2021, 11,9 ofMetabolites 2021, 11, x FOR PEER Review lites10 of 17 (10 metabolites: 2-lauroleic acid, 3-dodecenoicacid, 2-dodecenoicacid, linderic acid, C14:1N-7, C14:1N-10, C14:1N-12, gadoleic acid, 6-undecenoic acid and palmitelaidic acid) and saturated fatty acids metabolites (4 metabolites: myristic acid, pentadecanoic acid, stearic acid and lauric acid). 2.four. The Transform Degree of Metabolites during SM-SCIT and DM-SCITIn The Modify Degree of Metabolites through SM-SCIT and DM-SCIT two.4.order to distinguish the anti-inflammatory and proinflammatory levels between SM-SCIT and DM-SCIT, we used the ratio of alterations in metabolites’ levels to study the As a way to distinguish the anti-inflammatory and proinflammatory levels involving degree of metabolite adjustments in the course of treatment. In unique, the degree of alter of SM-SCIT and DM-SCIT, we utilized the ratio of alterations in metabolites’ levels to study the 11(S)-HETE in AR patients with SM-SCIT was considerably different from DM-SCIT (Figdegree of metabolite changes through remedy. In certain, the degree of modify of 11(S)ure five), indicating that the content of this element decreased much more in sufferers with SMHETE in AR patients with SM-SCIT was considerably different from DM-SCIT (Figure 5), SCIT. indicating that the content material of this component decreased much more in sufferers with SM-SCIT.Figure 5. Evaluation with the adjust degree of metabolic elements. (a) Comparison from the concentrations of 11(S)-HETE in between DM-SCIT and SM-SCIT groups in the pre-treatment stage (V0) to Figure five.initially stage from the transform degree of metabolic components. (a) Comparison with the concentra-Comthe Analysis on the upkeep phase (V2). The results have been expressed as mean SEM. (b) tions of 11(S)-HETE in between DM-SCIT and SM-SCIT
